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In all patients with a recent or remote history of myocardial infarction (MI) or acute coronary syndrome (ACS) and reduced EF, angiotensin-converting enzyme (ACE) inhibitors should be used to prevent symptomatic HF and reduce mortality.

In a 15-year prospective study of a community-dwelling people over the age of 60 years, the presence of diabetes at baseline significantly increased the age- and sex-adjusted incidence of all-cause dementia, Alzheimer disease, and vascular dementia compared with rates in those with normal glucose tolerance ().

In a case-control series, influenza vaccine was shown to reduce diabetes-related hospital admission by as much as 79% during flu epidemics ().

The phase 3 trial is also testing the drug in patients with cancer pain, interstitial cystitis, chronic low back pain, and diabetic nerve pain.

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Angelman syndrome is caused by an error in a gene located on chromosome 15 known as the ubiquitin protein ligase E3A UBE3A gene.

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