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Higher doses of a second-generation H 1-antihistamine are now recommended by some specialists for the treatment of chronic urticaria that does not respond to usual recommended doses.

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Among 300 cases of drug induced liver disease in the US collected between 2004 and 2008, one case was considered probably due to promethazine, but no other antihistamine was implicated).

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The competitive muscarinic antagonism of desloratadine in vitro and its potency and duration of action in vivo suggest that topical treatment of allergic conjunctivitis and rhinitis with desloratadine could produce undesirable peripheral anticholinergic side effects such as mydriasis and xerostomia.

However, by the time Schering submitted the drug to the (FDA) for approval, the agency had already approved a competitor's nonsedating antihistamine, (trade name Seldane), and, therefore, put loratadine on a lower priority.

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